Gene information
Official symbol ITGA2
Official full name integrin subunit alpha 2
Gene type protein-coding gene
Chromosome5q11.2
Alias symbolCD49b
Previous symbolCD49B
Gene familyCD molecules; Integrin alpha subunits
Resources
Entrez Gene 3673
HGNC HGNC:6137
Ensembl ENSG00000164171
Vega OTTHUMG00000131165
UCSC uc003joy.3
GO terms: 122 records
GO Description Category LogP Number of genes Detail
GO:0001540 amyloid-beta binding GO Molecular Functions -10.7345181 13 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001704 formation of primary germ layer GO Biological Processes -8.70692533 22 More
GO:0001889 liver development GO Biological Processes -10.3922429 25 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0006970 response to osmotic stress GO Biological Processes -4.47323224 7 More
GO:0007229 integrin-mediated signaling pathway GO Biological Processes -5.80936917 16 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009581 detection of external stimulus GO Biological Processes -2.05740021 12 More
GO:0009582 detection of abiotic stimulus GO Biological Processes -2.39356289 13 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010921 regulation of phosphatase activity GO Biological Processes -3.30329288 6 More
GO:0014075 response to amine GO Biological Processes -4.21089449 9 More
GO:0014823 response to activity GO Biological Processes -19.5783025 27 More
GO:0014850 response to muscle activity GO Biological Processes -5.74582458 8 More
GO:0014910 regulation of smooth muscle cell migration GO Biological Processes -16.4082106 27 More
GO:0014911 positive regulation of smooth muscle cell migration GO Biological Processes -11.1068742 16 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031644 regulation of nervous system process GO Biological Processes -8.22607591 24 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032965 regulation of collagen biosynthetic process GO Biological Processes -13.1192794 17 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033273 response to vitamin GO Biological Processes -22.1296854 31 More
GO:0033627 cell adhesion mediated by integrin GO Biological Processes -3.57905448 8 More
GO:0034250 positive regulation of cellular amide metabolic process GO Biological Processes -3.04911747 8 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0035303 regulation of dephosphorylation GO Biological Processes -3.02544423 7 More
GO:0035306 positive regulation of dephosphorylation GO Biological Processes -3.01689914 9 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0038065 collagen-activated signaling pathway GO Biological Processes -4.38810525 4 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042277 peptide binding GO Molecular Functions -10.2245210 22 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043388 positive regulation of DNA binding GO Biological Processes -12.0675836 19 More
GO:0043395 heparan sulfate proteoglycan binding GO Molecular Functions -6.54424039 8 More
GO:0043588 skin development GO Biological Processes -3.97728448 25 More
GO:0043679 axon terminus GO Cellular Components -2.06584249 11 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044306 neuron projection terminus GO Cellular Components -2.47884900 13 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0045178 basal part of cell GO Cellular Components -4.63395469 13 More
GO:0045727 positive regulation of translation GO Biological Processes -1.57399763 5 More
GO:0045807 positive regulation of endocytosis GO Biological Processes -11.0143833 14 More
GO:0045933 positive regulation of muscle contraction GO Biological Processes -10.2635447 16 More
GO:0045987 positive regulation of smooth muscle contraction GO Biological Processes -5.46031079 9 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050926 regulation of positive chemotaxis GO Biological Processes -15.5115450 16 More
GO:0050927 positive regulation of positive chemotaxis GO Biological Processes -14.3403642 15 More
GO:0050954 sensory perception of mechanical stimulus GO Biological Processes -4.15913068 20 More
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain GO Biological Processes -4.75202065 4 More
GO:0050974 detection of mechanical stimulus involved in sensory perception GO Biological Processes -3.21772170 4 More
GO:0050982 detection of mechanical stimulus GO Biological Processes -3.60984508 9 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051099 positive regulation of binding GO Biological Processes -11.1715489 31 More
GO:0051101 regulation of DNA binding GO Biological Processes -9.69427751 24 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051606 detection of stimulus GO Biological Processes -2.56190637 17 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0051969 regulation of transmission of nerve impulse GO Biological Processes -4.38810525 4 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061008 hepaticobiliary system development GO Biological Processes -10.9353398 26 More
GO:0062149 detection of stimulus involved in sensory perception of pain GO Biological Processes -4.25041921 7 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071260 cellular response to mechanical stimulus GO Biological Processes -11.7214175 13 More
GO:0071392 cellular response to estradiol stimulus GO Biological Processes -5.13834229 6 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0098636 protein complex involved in cell adhesion GO Cellular Components -5.90313372 12 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0150034 distal axon GO Cellular Components -2.90654836 23 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04145 Phagosome KEGG Pathway -11.4012504 17 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05222 Small cell lung cancer KEGG Pathway -6.83164026 10 More
hsa05412 Arrhythmogenic right ventricular cardiomyopathy KEGG Pathway -1.87478399 4 More
hsa05414 Dilated cardiomyopathy KEGG Pathway -7.04373804 18 More
Drug-Gene interaction
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Related drugs: 4 records
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
NM_002203.4:c.759C>T genomics myocardial infarction[diagnosis] myocardial infarction Santoso S et al. Blood. 1999
NM_002203.4:c.759C>T genomics myocardial infarction[diagnosis] myocardial infarction Zhao YH et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003
NM_002203.4:c.759C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Zhao Y et al. Chin Med Sci J. 2004
NM_002203.4:c.759C>T genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Antoniades C et al. J Am Coll Cardiol. 2006
NM_002203.4:c.[759C>T;873G>A] genomics myocardial infarction[diagnosis] myocardial infarction Moshfegh K et al. Lancet. 1999
NM_002203.4:c.[759C>T;873G>A] genomics platelet reactivity[other] myocardial infarction Giusti B et al. Atherosclerosis. 2008
NM_002203.4:c.672T>C genomics myocardial infarction[diagnosis] myocardial infarction Pina-Cabral LB et al. Rev Port Cardiol. 2018
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